Endocrine Abstracts

Objective: To study the metabolic profile of patients after surgery for pituitary tumors.Methods: This retrospective study included 1138 patients from 2000 to 2017. Those with prolactinomas, pituitary apoplexy and surgery elsewhere were excluded. The analysis included 525 patients, non-functional tumors (143), acromegaly (267), Cushing’s disease (113) and TSHoma (1). The patients’ blood pressure, blood sugar, lipid profile and body mass index (...

Objectives: Secondary Adrenal Insufficiency is diagnosed using an ACTH stimulation test. There is no clear evidence that either a Low dose Synacthen Test (LDST) or a Short Synacthen Test is more superior in diagnosis. In our service, we routinely use LDST to investigate adrenal function. There is a lack of standardisation regarding timing, dose and frequency whilst undertaking a LDST leading to diagnostic inconsistencies. We routinely measure baseline cortisol levels, then at ...

Background: Pituitary apoplexy is a neurological emergency, whose prevalence is generally underestimated. The overall prevalence ranges from 0.6 to 27.7% of all pituitary tumours.Methodology: Retrospective analysis of hospital medical records of 274 patients with pituitary adenoma who presented to us between 1996–2006 was done.Results: Of the 274 patients analysed, 84 had features of pituitary apoplexy (31%) Mean age was 44.7 ...

Introduction: Diabetes mellitus (DM) is frequently associated with vascular complications including diabetic microangiopathy. Nailfold capillaroscopy is a useful non-invasive diagnostic tool to identify changes in the microvascular architecture. Published literature hints at the presence of nailfold circulatory morphologic changes in diabetic patients.Objective: The purpose of the study was to identify by nailfold capillaroscopy microvascular changes in ...

Section 1: Case history: A case of a 23-year-old lady with a known history of Perthes disease, pulmonary stenosis, bronchial asthma, primary hypothyroidism on levothyroxine and newly diagnosed hypertension on amlodipine, who presented to Accident and Emergency with symptoms of generalised lethargy, weakness of the upper and lower limbs, rapid onset of weight gain for 6 months, increasing abdominal girth and recurrent genital thrush.Section 2: Investigati...

Introduction: Pituitary incidentalomas (PIs) defined as pituitary tumors discovered by systematic neuroimaging constitute an increasingly clinical problem. Most of PIs are nonfunctioning tumors (NFPIs) with systematic investigation revealing visual and/or endocrinological impairment in some patients while others remained asymptomatic. If the therapeutic management is well codified for functioning PIs and symptomatic NFPIs, a debate still remain for asymptomatic NFPIs between s...

Introduction: Various imaging modalities are used in the preoperative localization of insulinoma. CT is the modality that is in widespread use. Endoscopic ultrasound (EUS) allows the transducer to be placed in close proximity to the pancreas, thereby yielding images of higher quality, leading to accurate localization. An accurate preoperative localization results in a minimal invasive surgery and less occurrence of residual tumors, translating into a better clinical outcome. O...

Introduction: Craniopharyngiomas constitute 2–5% of all primary CNS neoplasms. We retrospectively analysed the case records of all patients with craniopharyngioma treated in our hospital from 1996 to 2006.Results: One hundred and twenty-seven patients were treated during this period. 65% were male and 35% were female. 50 patients (39%) were <15 yrs of age. The maximum clustering of cases was in the 6–15 yr age group (37%).<p class="abs...

Delayed hyponatraemia(DH) is a well-known complication following trans-sphenoidal pituitary surgery (TSS), varying in incidence from 9–36% and occurs between post-operative days(POD) 4 to 14. Various studies have demonstrated that post-operative fluid restriction after TSS reduces the incidence of DH.Objective: to assess whether a fluid restriction protocol from POD5 to POD14 following TSS reduces the incidence of post-operative DH ...

Objective: We report the rare case of a 45-year-old male with multiple endocrine neoplasm 1 (MEN1) with simultaneous occurrence characteristic tumours leading to a delicately balanced metabolic homeostasis.Methods: Clinical, biochemical, and radiological data of this patient diagnosed to have MEN1 were analysed and the challenges in the management of these neuroendocrine tumours are discussed.Case illustration: A 45-year-old gentle...